DMNQ

DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. The amount of oxidative stress is proportional to the amount of DMNQ applied and can alter diverse cellular parameters, including signal transduction, mitochondrial function, and gene expression.

DMNQ is a non-alkylating redox cycling quinone.

2,3-Dimethoxy-1,4-naphthoquinone has been used to investigate the effects of ethanol on podocyte apoptosis under hypoxic and hyperoxic conditions.

ChEBI: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necro is. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.

2,3-dimethoxy-1,4-naphthoquinone (DMNQ) has the ability to produce H2O2through redox cycling but fails to conjugate with glutathione (GSH).

+4°C

[1] TIMOTHY W. GANT . Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes[J]. Chemico-Biological Interactions, 1988, 65 2: Pages 157-173. DOI:10.1016/0009-2797(88)90052-x
[2] Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes
[3] J. DYPBUKT. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.[J]. The Journal of Biological Chemistry, 1994, 1 1: 30553-30560. DOI:10.1016/s0021-9258(18)43849-5
[4] T. R. HENRY  K. B W. Differential mechanisms of cell killing by redox cycling and arylating quinones[J]. Archives of Toxicology, 1996, 70 8: 482-489. DOI:10.1007/s002040050302