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Cystamine dihydrochloride

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Cystamine dihydrochloride Basic information
Cystamine dihydrochloride Chemical Properties
  • Melting point:217-220 °C (dec.)(lit.)
  • storage temp. Store below +30°C.
  • solubility H2O: soluble1.0g/10 mL, clear to almost clear, colorless to almost colorless (<5.5 NTU)
  • form Crystalline Powder, Crystals or Chunks
  • color White to yellow
  • Water Solubility soluble
  • Sensitive Hygroscopic
  • Merck 14,2776
  • BRN 3616850
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference56-17-7(CAS DataBase Reference)
  • EPA Substance Registry SystemEthanamine, 2,2'-dithiobis-, dihydrochloride (56-17-7)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36/37/38
  • Safety Statements 37/39-26-36/37/39
  • WGK Germany 3
  • RTECS KR7260000
  • TSCA Yes
  • HazardClass IRRITANT
  • HS Code 29309070
MSDS
Cystamine dihydrochloride Usage And Synthesis
  • Chemical Propertieswhite powder
  • Useshepatoprotectant, t-glutaminase inhibitor, heat shock protein promoter, caspase inhibitor
  • Usessulfhydryl modifying reagent and heparin antagonist
  • UsesCystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections. It is also used as a radiation-protective agent that interferes with sulfhydryl enzymes. Further, it serves as a heparin antagonist and sulfhydryl modifying reagent. In addition to this, it is used as an inhibitor of TGase.
  • Safety ProfileA poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl, SOx, and NOx. See also SULFIDES.
  • Purification MethodsRecrystallise the salt by dissolving in EtOH containing a few drops of dry EtOH/HCl, filtering and adding dry Et2O. The solid is dried in a vacuum and stored in a dry and dark atmosphere. It has been recrystallised from EtOH (solubility: 1g in 60mL of boiling EtOH) or MeOH (plates). The free base has b 90-Purification of Biochemicals — Amino Acids and Peptides 100o/0.001mm, 106-108o/5mm and 135-136o/760mm, d 4 1.1559, n D 1.5720. [Verly & Koch Biochem J 58 663 1954, Gonick et al. J Am Chem Soc 76 4671 1954, Jackson & Block J Biol Chem 113 137 1936.] The dihydrobromide has m 238-239o (from EtOH/Et2O) [Viscontini Helv Chim Acta 36 835 1953]. [Beilstein 4 H 287, 4 IV 1578.]
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