D-α-Tocopherol succinate

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2Tocopherol succinate induces apoptosis in human gastric cancer cells3and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

Off-White to Pale Yellow Solid

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

A potent antioxidant tocopherol

ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.

White powder.

Insoluble in water.

Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.

Not classified

Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.

When heated to decomposition it emits acrid smoke and irritating fumes.

[1] VIJAY K SINGH  Tzu C K  Darren S Brown. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.[J]. International Journal of Radiation Biology, 2010, 86 1: 12-21. DOI:10.3109/09553000903264515
[2] VIJAY K. SINGH  Tzu C K  Darren S Brown. Tocopherol succinate: A promising radiation countermeasure[J]. International immunopharmacology, 2009, 9 12: Pages 1423-1430. DOI:10.1016/j.intimp.2009.08.020
[3] KUN WU. c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells.[J]. World Journal of Gastroenterology, 2004, 10 8: 1110-1114. DOI:10.3748/wjg.v10.i8.1110
[4] MICHAEL STAPELBERG. alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors.[J]. Biochemical and biophysical research communications, 2004, 69 1: 636-641. DOI:10.1016/s0006-291x(04)00797-1
[5] EMMA SWETTENHAM. α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system[J]. Journal of Neurochemistry, 2005, 94 5: 1448-1456. DOI:10.1111/j.1471-4159.2005.03298.x