2-Bromo-1-ethylpyridinium tetrafluoroborate

2-Bromo-1-ethylpyridinium Tetrafluoroborate is a carboxyl activation and coupling reagent for peptide synthesis.

2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:

• The synthesis of N-methylated peptides in solution and solid phase.
• The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.

2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine.