Dimethyl sulfoxide-d6 is a sulfur-containing compound with the molecular formula (CD3)2SO. It is a colorless, odorless, transparent liquid at room temperature, with a freezing point of 18.45°C and a boiling point of 189°C. It has a slightly bitter taste and is highly soluble in water, alcohol, ether, and ester, exhibiting strong hygroscopic properties. DMSO remains stable below 140°C but decomposes into trace amounts of aldehydes, sulfides, and mercaptans when heated for extended periods at its boiling point. Decomposition accelerates under acidic conditions but can be inhibited in alkaline environments. Therefore, DMSO refining is typically performed via vacuum distillation, with the pH maintained around 8, or by adding sodium oxalate as a stabilizer.
DMSO-d6 is a solvent of choice in NMR spectroscopy, owing to its unique characteristics of dissolving both nonpolar and polar compounds, miscibility with almost all organic solvents and permitting high temperature dynamic NMR studies.
Dimethyl sulfoxide-d6 may be used as an NMR solvent for 1H and 13C NMR experiments.
(Dimethyl Sulfoxide-d6) DMSO is a very common aprotic solvent that is used in a variety of organic chemical reactions and spectroscopic analyses.
ChEBI: Dimethyl sulfoxide-d6 is a deuterated compound, a sulfoxide and a volatile organic compound.
Dimethyl sulfoxide-d6 (DMSO-d6) is a deuterated solvent. It is 100% isotopically enriched NMR (Nuclear Magnetic Resonance) solvent. It is widely employed in high resolution NMR studies due to its high chemical and isotopic purity. On photoirradiation in the range of 193 and 222nm, it undergoes decomposition to afford CD3 radicals. Quantum yields of CD3 have been evaluated by infrared diode laser absorption spectroscopy. 100% DMSO-d6 has been used as solvent in the long-range COSY (Correlation Spectroscopy) experiment.
Dimethyl sulfoxide (DMSO) and heavy water (DO) are reacted in the presence of a base catalyst. The deuterium exchange is performed multiple times: reaction at 90-95C, water removal at 130-150C, and repetition with fresh DO. The reaction mixture is distilled under reduced pressure to give a crude product (~99.2% deuteration). The crude product is recrystallized at 17C to yield high-purity deuterated DMSO (>99.8% deuteration).
