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Cyclosporin H

Basic information Safety Related Supplier
Cyclosporin H Basic information
Cyclosporin H Chemical Properties
  • Melting point:148-151°C
  • Boiling point:1293.8±65.0 °C(Predicted)
  • Density 1.016±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • pka13.32±0.70(Predicted)
  • form powder
  • color white to beige
  • optical activity[α]/D -100 to -115°, c = 0.5 in methanol
Safety Information
  • HS Code 29420000
Cyclosporin H Usage And Synthesis
  • Chemical PropertiesWhite Powder
  • UsesAn immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
  • UsesCyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
Cyclosporin H(83602-39-5)Related Product Information
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