MPP Dihydrochloride is a pharmacological estrogen receptor antagonist. It cannot block EE2 induced luciferase activity with any isoform of zebrafish estrogen receptor.
MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:
- in human breast cancer MCF-7 cells
- to pre-treat endometrial ex vivo organ cultures (EVOCs)
- to treat pituitary glands to monitor luteinizing hormone secretion
Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.
MPP dihydrochloride is a specific estrogen receptor α antagonist.
