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Unii-p9vxv1408y

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Unii-p9vxv1408y Basic information
Unii-p9vxv1408y Usage And Synthesis
  • Antimicrobial activityA semisynthetic cephalosporin formulated as the water-soluble fosamil acetate prodrug for intravenous administration. Its properties are similar to those of ceftobiprole, with which it shares an enhanced affinity for penicillin-binding protein 2′ (2a) of methicillin-resistant Staph. aureus. It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative bacilli.
  • PharmacokineticsCmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion
    Plasma half-life: 2.6 h
    Volume of distribution: 0.37 L/kg
    Plasma protein binding :<20%
    Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in plasma after intravenous infusion and excreted principally in urine. In preliminary clinical studies it appears to be well tolerated.
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