Basic information Selective Androgen Receptor Modulator Clinical Application Biological activity In vitro In vivo Characteristics Safety Related Supplier
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Endocrinology & Hormones >  Androgen Receptor agonists >  Andarine

Andarine

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.

Basic information Selective Androgen Receptor Modulator Clinical Application Biological activity In vitro In vivo Characteristics Safety Related Supplier
Andarine Basic information
Andarine Chemical Properties
  • Melting point:70-74℃
  • Boiling point:698.7±55.0 °C(Predicted)
  • Density 1.47
  • storage temp. Refrigerator
  • form neat
  • pka12.13±0.29(Predicted)
  • BRN 9666695
  • InChIKeyYVXVTLGIDOACBJ-SFHVURJKSA-N
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36
  • Safety Statements 26
  • WGK Germany 3
Andarine Usage And Synthesis
  • Selective Androgen Receptor Modulator

    Andarine (MK-2866), as the arylpropionamide derivate, has been developed in pharmaceutical industry as a new class of therapeutics called Selective Androgen Receptor Modulator (SARM, either agonists or antagonists at particular androgen receptors) with specific selectivity for particular tissues and organs, that could substitute the synthetic anabolic drugs used in medical treatments.

  • Clinical Application

    The pharmacological activity of andarine suggest the great potential of andarine in the development of the clinically available SARMs, which offers unique therapeutic advantages over their steroidal counterparts and an exciting opportunity to differentially regulate the androgen effects in various target tissues, thus minimizing the interference to normal. Thus, andarine has promising in advanced clinical trials that aim to treat age-related maladies and to counteract symptoms of severe diseases such as sarcopenia and cancer cachexia.
    However, andarine may be misused in sports where athletes and/or their handlers may seek to gain unfair advantage. Therefore, andarine as agonist is prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency.

  • Biological activityAndarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.
  • In vitroIn vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%.
  • In vivoIn vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.
  • CharacteristicsAndarine is a selective non-steroidal androgen receptor (AR) agonist.
  • Chemical PropertiesPale Yellow Solid
  • UsesIt is a potent and tissue-selective androgen receptor modulator (SARM)
Andarine(401900-40-1)Related Product Information
AndarineSupplierMore
  • Company Name:Medi-tech Bioscientific Co., Ltd. Gold
  • Tel:0519-83246372 13585352506
  • Email:sales@meditechbs.com
  • Products Intro:Product Name:Andarine (GTX-007)
    CAS:401900-40-1
    Purity:98% Package:5mg/10mg/100mg/1g/10g
  •  
  • Company Name:Shanghai hongqu biomedical technology co. LTD Gold
  • Tel:88888888888
  • Email:hongquchem@qq.com
  • Products Intro:Product Name:Andarine
    CAS:401900-40-1
    Purity:98% Package:100mg;1g;10g;100g;1kg
  •  
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  • Products Intro:Product Name:Andarine
    CAS:401900-40-1
    Package:2.5Mg,25Mg
  •  
  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Email:sales@BioChemBest.com
  • Products Intro:Product Name:Andarine
    CAS:401900-40-1
    Remarks:C14523
  •  
  • Company Name:Chemsky(shanghai)International Co.,Ltd.
  • Tel:021-50135380
  • Email:shchemsky@sina.com
  • Products Intro:Product Name:Andarine
    CAS:401900-40-1
    Purity:98%
  •  
Related articles