2,3-Dimethoxypyridine

52605-96-6

124-41-4

52605-97-7

To a three-necked flask was added 2-chloro-3-methoxypyridine (5.58 g, 39.0 mmol), N,N-dimethylformamide (60 mL) and sodium methanol (6.20 g, 115.0 mmol). The reaction mixture was stirred at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature, water (120 mL) was added and extracted with ethyl acetate (80 mL x 3). The organic phases were combined and washed sequentially with water (100 mL x 2) and saturated brine (100 mL), then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated by rotary evaporator to give 2,3-dimethoxypyridine (4.0 g, 28.9 mmol, 74% yield) as a yellow liquid.