3-aminopiperidine-2,6-dione hydrochloride is an important organic synthetic raw material for the preparation of the antineoplastic agent pomalidomide, which is used to treat AIDS-related kaposi's sarcoma in patients who have not responded well to highly active antiretroviral therapy (HAART). It is also used to treat Kaposi's sarcoma in HIV-uninfected (HIV-negative) patients.
3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce?ubiquitination and degradation of CK1α in del(5q) MDS.?It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
