Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/Rassociated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl2 is significantly downregulated. The expression of active caspase3 and Bax is significantly downregulated by Morroniside treatment in a dosedependent manner, while the expression of Bcl2 is significantly upregulated[1]. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice[2].
