3-Phenyl-1H-pyrazole

3-phenyl-1H-pyrazole is an essential intermediate for the synthesis of many biologically active compounds. It was synthesized from acetophenone and hydrazine through two steps, including Knoevenagel condensation and cyclization reaction[1]. As the ligand, this compound could synthesize a novel luminescent cyclometalated iridium(III) complex-based chemosensor bearing a zinc-specific receptor. This Luminescent Iridium(III) Chemosensor could visualize Zn2+ Ions in Live Zebrafish[2].

white to yellowish-orange powder

[1] X. Liu. et al. “Synthesis of 3-phenyl-1H-pyrazole Derivatives.”. DOI 10.2991/emcm-16.2017.117.
[2] Dik-Lung Ma*. “Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor.” ACS Applied Materials & Interfaces 6 16 (2014): 14008–14015.