氯苄哌醚联苯酰苯酸盐
氯苄哌醚联苯酰苯酸盐 性质
| 熔点 | 185-187°C |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
| InChIKey | PXZFKAKWSHBDCP-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(Cl)=CC=1)OCCN1CCCCC1.OC1=CC=C(C(C2C=CC=CC=2C(=O)O)=O)C=C1C1C=CC=CC=1 |
氯苄哌醚联苯酰苯酸盐 用途与合成方法
27 nM (K + currents)
Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.
氯苄哌醚联苯酰苯酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-B2179 | 氯苄哌醚联苯酰苯酸盐 | 85187-37-7 | 500mg | 300 |
| 2025-12-22 | HY-B2179 | 氯苄哌醚联苯酰苯酸盐 | 85187-37-7 | 1 g | 450 |
