基本属性 生物活性靶点体外研究体内研究 用途与合成方法 151227-08-6 价格(试剂级) 供应商

151227-08-6

151227-08-6

中文名称:151227-08-6
英文名称:AP521
CAS号:151227-08-6
分子式:C20H19ClN2O3S
分子量:402.89
EINECS号:
Mol文件:151227-08-6.mol
151227-08-6 结构式

151227-08-6 性质

储存条件 Store at -20°C
溶解度 溶于二甲基亚砜

151227-08-6 用途与合成方法

AP521 是一个人 5-HT1A 受体激动剂,其 IC50 值为 94 nM。

5-HT 1A Receptor

94 nM (IC 50 , in human)

5-HT 1A Receptor

135 nM (IC 50 , in rat)

5-HT 1B Receptor

254 nM (IC 50 , in rat)

5-HT 1B Receptor

5530 nM (IC 50 , in human)

5-HT 1D Receptor

418 nM (IC 50 , in human)

5-HT 5A Receptor

422 nM (IC 50 , in human)

5-HT 7 Receptor

198 nM (IC 50 , in rat)

AP521 is an agonist of human 5-HT 1A receptor with IC 50 s of 135, 94, 254, 5530, 418, 422 and 198 nM for 5-HT 1A (rat), 5-HT 1A (human), 5-HT 1B (rat), 5-HT 1B (human), 5-HT 1D (human), 5-HT 5a (human) and 5-HT 7 (rat), respectively. AP521 also decreases the forskolin-induced cAMP accumulation from 10 nM to 10 μM.

AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant.

151227-08-6 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-100166 151227-08-6 151227-08-6 5 mg 1700
2024-01-25 HY-100166 10 mg 3000

151227-08-6供应商 更多

成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
英文名称:AP521
CAS:151227-08-6
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223
产品介绍:
英文名称:AP521
CAS:151227-08-6
包装信息:100mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 T10344
英文名称:AP521;AP521,AP-521
CAS:151227-08-6
纯度:98%
包装信息:5 mg
苏州美石生物科技有限公司
联系电话: 1173954148q
产品介绍:
英文名称:151227-08-6
CAS:151227-08-6
纯度:99% HPLC
包装信息:1G;5G;10G;100G;1KG;
备注:医药级