Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)

Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4).2,3 It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 µM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial cells (HUVECs) by 80% after 12 hours in an in vitro wound closure assay.4 NPY (3-36) corresponds to residues 3-36 of the human and rat protein sequence.WARNING This product is not for human or veterinary use.

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[2] D GRANDT . Neuropeptide Y 3–36 is an endogenous ligand selective for Y2 receptors[J]. Regulatory Peptides, 1996, 67 1: Pages 33-37. DOI: 10.1016/s0167-0115(96)00104-8
[3] MARGARET DOS SANTOS MEDEIROS   A J T. Metabolism and functions of neuropeptide Y[J]. Neurochemical Research, 1996, 21 9: 1125-1132. DOI: 10.1007/bf02532423
[4] GUILIO GHERSI . Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding[J]. Peptides, 2001, 22 3: Pages 453-458. DOI: 10.1016/s0196-9781(01)00340-0