Sodium diethyldithiocarbamate trihydrate

white to light yellow crystals

Sodium diethyldithiocarbamate trihydrate is a spin trapping reagent used in conjunction with ferrous ion to detect nitric oxide in brain, kidney, liver and other tissues. It is used as sensitive reagent for the determination of copper, rubber vulcanization accelerator and finds application in the determination of other metals such as zinc, cobalt, platinum and palladium. Furthermore, it is an inhibitor of superoxide dismutase, ascorbate oxidase and other enzymes as well as inhibits the induction of macrophage nitric oxide synthase.

Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. Sodium diethyldithiocarbamate trihydrate is a copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.

A possible nuclear factor kappa B inhibitor.

Sodium diethyldithiocarbamate trihydrate may be used:

• To synthesize cis-dichlorobis(N,N-diethyldithiocarbamato) tin(IV) by reacting with tin(II) chloride.
• As an alternative to xanthates to generate carbamoyl radical precursors.
• To synthesize a soluble precursor polymer for poly(thienylene vinylene).
• To synthesize dichlorotetrakis(dimethyl sulfoxide)ruthenium (II), which can be a precursor to prepare other ruthenium complexes.[17}

Inhibits induction of macrophage nitric oxide synthase.

Recrystallise it from water. [Beilstein 4 III 224, 4 IV 390.]