Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs).
1 Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC
50 value of 11.8 μM.
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1. Cohen, L.J., Kang, H.S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist Proc. Natl. Acad. Sci. USA 112(35),E4825-E4834(2015).
