1333210-07-3
1333210-07-3 性质
| 沸点 | 534.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 不溶于水；乙醇中≥106.4 mg/mL； DMSO 中≥125.4 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.95±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
1333210-07-3 用途与合成方法
| Target | Value |
|
TPRC6
(Cell-free assay) | 7.9nM |
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca 2+ influx into cells with IC 50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca 2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC 50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.
SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
1333210-07-3 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-15699 | 1 mg | 909 | ||
| 2024-11-08 | HY-15699 | 1333210-07-3 | 1333210-07-3 | 5mg | 2000 |
