CAY10638

Prostaglandins have a short life in vivo because NAD⁺-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.¹ Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.^2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.³

ChEBI: CAY10638 is an aromatic ether.

1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R. Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010).