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Ethyl 4-piperidinecarboxylate

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Ethyl 4-piperidinecarboxylate Basic information
Ethyl 4-piperidinecarboxylate Chemical Properties
  • Boiling point:204 °C(lit.)
  • Density 1.02 g/mL at 25 °C(lit.)
  • refractive index n20/D 1.459(lit.)
  • Flash point:176 °F
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • form Liquid
  • pka9.83±0.10(Predicted)
  • color Clear colorless to slightly brown
  • Water Solubility miscible
  • BRN 118419
  • CAS DataBase Reference1126-09-6(CAS DataBase Reference)
  • NIST Chemistry ReferenceEthyl piperidine-4-carboxylate(1126-09-6)
Safety Information
  • Hazard Codes C,Xi
  • Risk Statements 34-36/37/38
  • Safety Statements 23-24/25-36-26
  • RIDADR UN2735
  • WGK Germany 3
  • Hazard Note Irritant
  • HS Code 29333999
MSDS
Ethyl 4-piperidinecarboxylate Usage And Synthesis
  • Chemical Propertiesclear colorless to slightly brown liquid
  • UsesReactant for synthesis of:• ;SMN protein modulators1• ;β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• ;Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• ;RhoA inhibitors for cardiovascular disease therapy4• ;Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6
  • UsesReactant for synthesis of SMN protein modulators and β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition.
  • UsesIt is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.
  • Synthesis Reference(s)Tetrahedron Letters, 23, p. 193, 1982 DOI: 10.1016/S0040-4039(00)86783-0
Ethyl 4-piperidinecarboxylate Preparation Products And Raw materials
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