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Dihydrostreptomycin sulfate

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Dihydrostreptomycin sulfate Basic information
Dihydrostreptomycin sulfate Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 24/25
  • WGK Germany 3
  • RTECS WK2236000
  • TSCA Yes
  • HS Code 29412030
Dihydrostreptomycin sulfate Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • OriginatorDihydrostrepto,MSD ,US,1948
  • UsesAs a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
  • Usesantibacterial, tuberculostatic
  • Manufacturing ProcessDihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
  • Therapeutic FunctionAntibiotic
  • Purification MethodsIt crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]
Dihydrostreptomycin sulfate(5490-27-7)Related Product Information
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