Dihydrostrepto,MSD ,US,1948
Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
antibacterial, tuberculostatic
As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by
catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction
(Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or
by isolation from a fermentation process (Takeda).
It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]
