Acrinathrin is a synthetic pyrethroid that has a high insecticidal activity against a range of insects including mites. It has a low aqueous solubility, is semi-volatile and, based on its chemical properties, should not leach. Laboratory studies suggest it is moderately persistent in soils but will rapid degrade in aqueous systems. It has a low toxicity to humans but there is some concern that it may bio-accumulate. Acrinathrin is highly toxic to bees and most aquatic species, moderately toxic to birds and earthworms.
Pure product is white crystal, odorless. m.p.81.5°C, vapor pressure 390×10-9Pa (25°C), [α]20D+17.5 o. Solubility at 25°C: easily soluble in acetone, chloroform, dichloromethane, ethyl acetate, dimethylformamide, solubility>500g/L, diisopropyl ether170g/L,ethanol40g/L,hexane10g/L, water≤0.02mg/L. Distribution system sensitive180000.Stable in acidic medium, hydrolysis and differential isomerization occurs at pH>7, under 100W light. 0.02mg/L. Distribution system is sensitive to 180000, stable in acidic medium, hydrolysis and differential isomerization occurs when pH>7, the original drug can be stabilized for 1 week under 100W light, easy to be adsorbed and fixed by soil.
ChEBI: Acrinathrin is a cyclopropanecarboxylate ester and an organofluorine compound. It has a role as a pyrethroid ester insecticide and a pyrethroid ester acaricide. It is functionally related to a diphenyl ether.
Acrinathrin is manufactured through a complex multi-step chemical synthesis designed to produce a single, highly active isomer of this pyrethroid insecticide. The process begins with the preparation of key building blocks such as cyano(3-phenoxyphenyl)methanol and a substituted cyclopropane carboxylic acid derivative containing trifluoromethyl groups. These components are then esterified under controlled conditions to form the acrinathrin molecule, which features three chiral centres and a double bond, resulting in 15 possible isomers, though only one is used commercially due to its superior insecticidal activity.
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