2-Nitro-4-fluorophenol

371-41-5

394-33-2

The general procedure for the synthesis of 2-nitro-4-fluorophenol from 4-fluorophenol was as follows: silica-loaded Al(NO3)3-9H2O (1 mmol) was added to a solution of 4-fluorophenol (1 mmol) in acetone (5 mL) and the reaction mixture was stirred at room temperature. The reaction process was monitored by TLC. Upon completion of the reaction, the reaction mixture was filtered and the silica residue was washed with ethyl acetate (25 mL). The filtrate and washings were combined and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) to give 2-nitro-4-fluorophenol (95%) and 4-nitro-4-fluorophenol (3%).