盐酸利莫那班
盐酸利莫那班 性质
| 熔点 | 230-240°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChI | 1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H |
| InChIKey | REOYOKXLUFHOBV-UHFFFAOYSA-N |
| SMILES | CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NN4CCCCC4)=O.Cl |
| CAS 数据库 | 158681-13-1(CAS DataBase Reference) |
盐酸利莫那班 用途与合成方法
|
CB1 1.8 nM (Ki) |
Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant.
Rimonabant itself (10
-12
-10
-3
M, 12 concentrations) inhibits the basal binding of [
35
S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC
50
of 4.7±0.2 (IC
50
= 20 μM) and a maximal inhibition of 48±2%.
Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant .
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors.
安全信息
| 危险品标志 | T,Xi |
|---|---|
| 危险类别码 | 25-36 |
| 安全说明 | 26-45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 急性毒性 类别3经口 眼部刺激 类别2 |
盐酸利莫那班 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-14137 | 盐酸利莫那班 | 158681-13-1 | 1 mg | 165 |
| 2025-12-22 | HY-14137 | 盐酸利莫那班 | 158681-13-1 | 5 mg | 331 |
