Tripelennamine hydrochloride

White Solid

Tripelennamine is a first-generation antihistamine, used in the treatment of asthma, hay fever, and urticaria.

antihistaminic;histamine H1 antagonist

PBZ (Novartis).

Tripelennamine hydrochlorideis a white crystalline powder that darkensslowly on exposure to light. The salt is soluble in water(1:0.77) and in alcohol (1:6). It has a pKa of about 9, and a0.1% solution has a pH of about 5.5.
Tripelennamine, the first ethylenediamine developed inthe United States and is well absorbed when given orally. Itappears to be as effective as diphenhydramine and may havethe advantage of fewer and less severe side reactions.Drowsiness may occur, however, and may impair the abilityto perform tasks requiring alertness. The concurrent use ofalcoholic beverages should be avoided.

Odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56.

Water soluble.

TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.