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Flufenamic acid

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Flufenamic acid Basic information
Flufenamic acid Chemical Properties
  • Melting point:132-135 °C(lit.)
  • Boiling point:373.9±42.0 °C(Predicted)
  • Density 1.3380 (estimate)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • pkapKa 3.9 (Uncertain);3.85 (Uncertain)
  • form Crystalline Powder or Chunks
  • color Off-white to gray-green
  • Water Solubility 0.0265 g/L (37 ºC)
  • Merck 14,4132
  • BRN 1996069
  • CAS DataBase Reference530-78-9(CAS DataBase Reference)
  • NIST Chemistry ReferenceFlufenamic acid(530-78-9)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36/38
  • Safety Statements 26
  • RIDADR UN 2811 6.1/PG 3
  • WGK Germany 3
  • RTECS CB4375000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29224999
  • ToxicityLD50 in mice: 715 mg/kg orally (Zoni)
MSDS
Flufenamic acid Usage And Synthesis
  • Chemical PropertiesPale-Yellow Solid
  • OriginatorFlufenamic acid,AroKor Holdings Inc.
  • UsesFlufenamic acid is used for moderate pain and dysmenorrhea, but it should not be used for more than 1 week due to the possibility of nephrotoxicity, gastrointestinal toxicity, and anemia. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid.
  • UsesAnti-inflammatory; analgesic
  • Manufacturing ProcessA mixture 31.3 g of o-chlorobenzoic acid, 32.2 g of trifluoromethyl-maminobenzene, 3 g of copper powder, 13.8 g of waterless potassium carbonate and 100 ml amyl alcohol was refluxed for 4 hours. To the cooled mixture was added 25 ml of 10 N solution NaOH and the mixture was concentrated and filtrated. Addition to the filtrate hydrochloric acid and water give a sediment of 2-((3-trifluromethyl)phenyl)aminobenzoic acid. After recrystallization from hexane 2-((3-trifluromethyl)phenyl)aminobenzoic acid have melting point 134-136°C.
  • brand nameArlef (Parke-Davis).
  • Therapeutic FunctionAntiinflammatory, Antirheumatic
  • Chemical SynthesisFlufenamic acid, N-(α,α,α-trifluoro-m-tolyl)anthranylic acid (3.2.18), is synthesized by the reaction of 2-chlorobenzoic acid with 3-trifluoromethylaniline in the presence of potassium carbonate and copper filings [78,79].

Flufenamic acid Preparation Products And Raw materials
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