Cocamidopropyl betaine (CAPB) is an amphoteric surfactant. The particular behaviour of amphoterics is related to their zwitterionic character; that means: both anionic and cationic structures are found in one molecule.
Cocamidopropyl betaine is widely used as a surfactant. The usage of cocamidopropyl betaine in personal-care products has grown in recent years due to its relative mildness compared with other surface active compounds. Cocamidopropyl betaine is widely used in various cosmetics like shampoos, bath products, and cleansing agents, shower gels, bath foam, liquid soaps, skin care products, hand wash detergents. Uses in household cleaning products, the scope of HERA, include laundry detergents, hand dishwashing liquids, and hard surface cleaners.
Skin irritation: According to current OECD guideline, cocamidopropyl betaine (about 30% aqueous solution and nearly 80% spray-dried substance) is not a skin irritant. In human studies up to 3 % solutions were weakly irritating. Impurities like amidoamine may contribute to the irritation reaction. The irritating properties of sodium lauryl sulphate formulations could be significantly reduced by the addition of cocamidopropyl betaine.
Eye irritation: The concentrated and the 25 - 30 % active cocamidopropyl betaine is an irreversible eye irritant. The 15 % concentrations were irritating to highly irritating. At and below 10% active dilution studies show a mild to moderate and reversible eye irritating potential of cocamidopropyl betaine.
The acute oral and dermal toxicity of cocamidopropyl betaine 30 – 35.5 % active solution in rats is low. The LD50 (dermal) is > 2000 mg/kg bw (which was the highest dose applied), LD50 (oral) is ≥ 4900 mg/kg bw. There were no clinical signs reported after acute dermal exposure; after oral exposure to high doses, decreased motor activity, diarrhea, and ataxia as well as signs of gastrointestinal irritation were found.
Cocamidopropyl Betaine (CAB) is an organic compound derived from coconut oil and dimethylaminopropylamine. It is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate. CAB is available as viscous pale yellow solution that is used as a surfactant in personal care products.
Cocamidopropyl Betaine (CAB) is perfectly compatible with anionic, cationic and nonionic surfactants, it can still be used as cloudy point inhibitor.
CAB can produce rich and fine foams. Fonnulated with adequate proportion of anionic surfactant, it has significant thickening effect.
CAB has excellent to tolerance to skin, effectively reduce the irritation caused by fatty alcohol sulfate or fatty alcohol ether sulfate in the products.
CAB has antibiotic function, being a good additive in personal sanitary products. CAB has excellent antistatic function, being an ideal conditioning agent.
Lonzaine(R) CO is a mild, high foaming, biodegradable cocoamidopropyl betaines. Suggested applications: foam booster for shampoos.
Cocamidopropyl betaine is a surfactant in liquid soaps, shampoos, hair colorants, shower and bath formulations.
Cocamidopropyl betaine is used in cosmetics and personal hygiene products (eg, shampoos, contact lens solutions, toothpaste detergents, makeup removers, bath gels, skin care products, cleansers, liquid soaps, antiseptics, and gynecologic and anal hygiene products).
ChEBI: A mixture of carboxamidopropyl betaines derived from fatty acids of varying chain lengths. The principal component is lauramidopropyl betaine.
Flammability and Explosibility
Not classified
Cocamidopropyl betaine is a pseudo-amphoteric zwitterion
detergent derived from long-chain alkylbetaines. It is available
from many suppliers under more than 50 trade names
(including Tego-betain L7 and Ampholyt JB 130). Exposure
occurs via rinse-off products such as liquid soaps, shampoos,
and shower gels, but also via leave-on products (for
example, roll-on deodorant). Occupational sources are
mainly in hairdressing. The first synthesis step consists of
the reaction of coconut fatty acids with 3-dimethylaminopropylamine,
giving cocamidopropyl dimethylamine. This
amido amine is converted into cocamidopropyl betaine by
reaction with sodium monochloroacetate. Both dimethylaminopropylamine
and cocamidopropyl dimethylamine
are thought to be the sensitizers.
In the original sealed containers and at temperature between 0°C and 40°C, this product remains stable at least one year. On account during its high salt content the product can have a Corrosive effect during storage in stainless steel tanks.
