法南色林
法南色林 性质
| 熔点 | 95-97 °C(Solv: acetonitrile (75-05-8)) |
|---|---|
| 沸点 | 641.1±65.0 °C(Predicted) |
| 密度 | 1.331±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.31±0.10(Predicted) |
法南色林 用途与合成方法
|
5-HT 2 Receptor 0.37 nM (Ki) |
D 4 Receptor 2.93 nM (Ki) |
Fananserin is relatively selective for 5-HT
2
receptor, having lower affinity for the 5-HT
1A
receptor and very low affinity for the 5-HT
3
receptor.
Fananserin displaces [
3
H]spiperone binding to recombinant human dopamine D 4 receptors with a K
i
of 2.93 nM.
RP 62203 displays low to moderate affinity for α1-adrenoceptors, dopamine D2 receptors and histamine H
1
receptors.
Fananserin displaces
[125I]
AMIK from 5-HT
2
receptors with an IC
50
of 0.21 nM in rat frontal cortex.
Fananserin shows moderate affinity for alpha 1-adrenoceptors in the rat thalamus (IC
50
= 14 nM) and for histamine H1 receptors in the guinea-pig cerebellum (IC
50
= 13 nM).
Fananserin (0.5-4 mg/kg; p.o.) increases the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner.
| Animal Model: | Adult male Sprague Dawley rats (250-300 g) |
| Dosage: | 0.5 mg/kg, 1 mg/kg,2 mg/kg, 4 mg/kg |
| Administration: | Oral administration |
| Result: | Increased the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner from 0.5 mg/kg. |
法南色林 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-103104 | 1 mg | 365 | ||
| 2024-11-08 | HY-103104 | 法南色林 | 127625-29-0 | 5mg | 740 |
