139290-65-6
139290-65-6 性质
| 熔点 | 89-91°C |
|---|---|
| 沸点 | 499.4±45.0 °C(Predicted) |
| 密度 | 1.150±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.93±0.20(Predicted) |
| 颜色 | 灰白色至浅棕色 |
139290-65-6 用途与合成方法
| Target | Value |
|
5-HT2 receptor
(Cell-free assay) | 0.36 nM(Ki) |
Volinanserin (MDL 100907) is a potent antagonist at the 5-HT 2 receptor, with a K i of 0.36 nM, and shows 300-fold selectivity for 5-HT 2 receptor over 5-HT 1c receptor, alpha-1 and DA D 2 receptors. Volinanserin has antipsychotic activity.
Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED 50 of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED 50 of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of desipramine in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of tranylcypromine.
139290-65-6 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-14940 | 139290-65-6 | 139290-65-6 | 5mg | 1100 |
| 2024-04-30 | HY-14940 | 139290-65-6 | 139290-65-6 | 10mM * 1mLin DMSO | 1210 |
