Palmitoyl Pentapeptide-3 is a synthetic protein that is a fragment of the C-terminal portion of collagen I (the most common type of the nineteen forms of collagen) combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. One could look at Palmitoyl Pentapeptide-3 as a man-made precursor to collagen I. When this protein is added to cultured human fibroblasts it enhances the synthesis of collagen I, collagen III and fibronectin. In vitro, Palmitoyl Pentapeptide-3 was found to stimulate collagen IV synthesis by 100-327% and to stimulate hyaluronic acid synthesis by 267%. In vivo Palmitoyl Pentapeptide-3 was found to stimulate collagen synthesis by 30-117%.
Palmitoyl Pentapeptide-3 (SpecPed? SC-PP4（0.01%)) is a lipophilic modified peptide originally developed for wound healing research and currently being investigated as an anti-aging ingredient. It helps to prevent fine lines induced by repeated facial movements and increased collagen and elastin matrix. This product also prevents premature aging with visible results within two weeks.