O-benzylhydroxylamine used in the synthesis of alfa- hydroxybenzylamines from alfa-hydroxyketones. It is also involved in the preparation of hydroxylamines and hydroxyamates.
A reagent for the preparation of N-hydroxyamides (including N-hydroxypeptides and N-hydroxyβ-lactams) and hydroxamic acids; a derivatizing agent for ketones, aldehydes and carbohydrates.
The free base O-benzylhydroxylamine, a liquid of bp 115-119 °C/30 mmHg, is easily prepared from the commercially available hydrochloride salt. For many reactions, however, it is preferable to generate the free base in situ from the salt.
Store in a cool dry place to preclude contact with moisture and oxygen; may be harmful by inhalation, ingestion, or skin absorption; avoid contact with the eyes.
