N-Ethylaniline is a yellow brown oil with aweak fishy odor. Molecular weight = 121.20; Boilingpoint = 205℃; Freezing/Melting point = -64℃; Flashpoint = 85℃ (oc). Flammable Limits: LEL 1.6%; UEL9.5%. Hazard Identification (based on NFPA-704 M RatingSystem): Health 3, Flammability 2, Reactivity 0. Insolublein water.
N-Ethylaniline is yellow-brown oil with a
weak fishy odor.
Polyethylene bottles used in intravenous solutions have been reported to be contaminated with N-ethylaniline from rubber parts of the closure (Ulsaker and Teien 1979). It has been reported that rubber containing N,N,-dithiodimorpholine accelerator of vulcanization can release N-ethylaniline into an aqueous media (Stankevich and Shurupova 1976). This compound has also been reported as a contaminant of cigarette smoke at a level of 55.8 ng per one U.S. 85 mm cigarette (Patrianakos and Hoffmann 1979).
N-Ethylaniline (NEA) may be used as an internal standard in the GC analysis of nicotine extraction from nicotine gum. It may be used in the synthesis of the following, 2-(N-ethylphenylamino)-1,4-benzoquinone, 2-(arylaminomethyl)phenylboronic acid, poly(methyl methacrylate) (PMMA) films containing NEA and poly(N-ethylaniline) (PNEA).
N-Ethylaniline is used as an explosive stabilizer and in
dyestuff manufacture.
Manufacture of N-ethylaniline is based on the reaction of aniline with alkyl halide or by heating aniline with ethyl alcohol under acidic conditions followed by purification (Windholz et al 1983).
ChEBI: N-Ethylaniline is a member of benzenes.
A dark liquid with an aromatic odor. Insoluble in water. Density 0.963 g / cm3. Toxic by skin absorption and inhalation of vapors. Evolves toxic fumes during combustion. Flash point 185°F.
Unstable to prolonged exposure to air and/or light. Insoluble in water.
N-Ethylaniline may react violently with nitric acid. May react with strong oxidizing agents. . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Toxic by ingestion, inhalation, and skin
absorption.
N-Ethylaniline is considered very hazardous in a fire situation, since it is highly toxic and readily absorbed by the inhalation, dermal and oral routes (HSDB 1988). Excessive exposure causes respiratory paralysis.
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
N-Ethylaniline is used as an explosives stabilizer and as an intermediate in the manufacturing of dyes and pharmaceuticals (Northcott 1978).
Poison by ingestion and
intraperitoneal routes. Moderately toxic by
an unspecified route. Mddly toxic by skin
contact. An allergen. Flammable when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use dry
chemical, CO2, foam. Hypergolic reaction
with red fuming nitric acid. When heated to
decomposition or on contact with acid or
acid fumes it emits highly toxic fumes of
aniline and NOx.
This material is used as an intermediate in dyes, pharmaceuticals and explosives; in organic
synthesis.
Eye Contact: Immediately remove any contactlenses and flush with large amounts of water for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention if any symptoms are present.Skin Contact: Quickly remove contaminated clothing.Immediately wash area with large amounts of soap,promptly seek medical attention.Breathing: Remove the person from exposure. Begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility.Note to physician: Treat for methemoglobinemia.Spectrophotometry may be required for precise determination of levels of methemoglobinemia in urine.
The metabolism of N-ethylaniline has been studied more as a tool to understanding microsomal drug metabolizing activity than as the central item of inquiry. However, the following have been clearly defined as metabolic products of N-ethylaniline: phenylhydroxylamine, N-hydroxyl, N-ethylaniline; N-ethyl-p-aminophenol; and aniline (Appel et al 1965; Heinze 1970; Hlavica 1970; Hlavica and Kiese 1969; Kampffmeyer and Kiese 1965; Kroeber et al 1970; Lange 1967 and Lange 1968). Nonmicrosomal metabolism has not been reported. Species shown capable of metabolism include rabbit, mouse, rat, dog, pig, and guinea pig with the proportions of the various metabolites often species dependent. Compounds similar to N-ethylaniline such as N-methyl-N-ethylaniline can form N-ethylaniline via demethylation (Gorrod et al 1975a,b).
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Ethylaniline must be stored to avoid contact withstrong acids (such as hydrochloric, sulfuric, and nitric) andstrong oxidizers since violent reactions occur. Store intightly closed containers in a cool, well-ventilated area.Sources of ignition, such as smoking and open flames, areprohibited where ethylaniline is used, handled, or stored ina manner that could create a potential fire or explosionhazard.
UN2272 N-Ethylaniline, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials
May form explosive mixture with air.
Decomposes on contact with light or air. Reacts with many
materials. Neutralizes acids in exothermic reactions to form
salts plus water. Flammable gaseous hydrogen may be generated in combination with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Contact with
strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from
alkaline materials; strong acids, such as nitric acid, can
cause fire; explosions with formation of toxic vapors of
aniline and oxides of nitrogen; strong bases, isocyanates,
halogenated organics, phenols (acidic), epoxides, anhydrides, and acid halides
