Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2].
| Animal Model: | Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] |
| Dosage: | 30 mg/kg, 60 mg/kg |
| Administration: | p.o.;once a day; for 7 days |
| Result: | Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
