871543-07-6
871543-07-6 性质
| 熔点 | 182-184°C |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| 溶解度 | 溶于甲醇、水 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1 |
| InChIKey | BFOPDSJOLUQULZ-GXKRWWSZSA-N |
| SMILES | [S](=O)(=O)(N3[C@H](CNCCC3)C)c1c2c(cncc2C)ccc1.Cl.Cl |
871543-07-6 用途与合成方法
|
ROCKII 12 nM (IC 50 ) |
CaMKII 0.18 μM (IC 50 ) |
PKG 0.36 μM (IC 50 ) |
AuroraA 0.745 μM (IC 50 ) |
PKA 3.03 μM (IC 50 ) |
Src 3.06 μM (IC 50 ) |
PKC 5.68 μM (IC 50 ) |
Abl 7.77 μM (IC 50 ) |
MKK4 16.9 μM (IC 50 ) |
MLCK 28.3 μM (IC 50 ) |
EGFR 50 μM (IC 50 ) |
GSK3α 60.7 μM (IC 50 ) |
AMPK 100 μM (IC 50 ) |
P38α 100 μM (IC 50 ) |
H-1152 dihydrochloride is an inhibitor of Rho-kinase, with an IC 50 of 12 nM for ROCK2. H-1152 (H-1152P) also shows less inhibitory activities against CaMKII, PKG, AuroraA, PKA, Src, PKC, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC 50 s of 0.180, 0.360, 0.745, 3.03, 3.06, 5.68, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively. H-1152 potently inhibits Rho kinase, with a K i of 1.6 nM, and slightly suppresses PKA, PKC and MLCK, with K i s of 0.63, 9.27, and 10.1 μM, respectively. H-1152 (0.1-10 µM) highly inhibits MARCKS phosphorylation, with an IC 50 value of 2.5 µM in LPA-treated cells, but shows no such obvious effects in PDBu-treated cells. H-1152 (0.5-10 μM) cuases no decreased neuronal survival. H-1152 (1, 5 or 10 μM) also exerts no alterations in the ratios of different neuronal morphologies. Furthermore, H-1152 (10 μM) increases neurite length in both BMP4 and LIF cultures.
871543-07-6 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-15720A | 871543-07-6 | 871543-07-6 | 1 mg | 673 |
| 2025-12-22 | HY-15720A | 871543-07-6 | 871543-07-6 | 2mg | 950 |
