MLN-4760
MLN-4760 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
| InChIKey | NTCCRGGIJNDEAB-IRXDYDNUSA-N |
| SMILES | C(O)(=O)[C@H](CC1N(CC2=CC(Cl)=CC(Cl)=C2)C=NC=1)N[C@H](C(O)=O)CC(C)C |
MLN-4760 用途与合成方法
| Target | Value |
|
ACE2
(Cell-free assay) | 0.44 nM |
|
CPDA
(Cell-free assay) | 27 μM |
MLN-4760 is a potent and selective human ACE2 inhibitor (IC 50 , 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes human testicular ACE (IC 50 , >100 μM) and bovine carboxypeptidase A (CPDA; IC 50 , 27 μM). MLN-4760 effectively quenches cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2. MLN-4760 shows pIC 50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC 50 at rhACE2 of 4.7±0.1, 6.9±0.1 and at ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), resepctively.
MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly worsens neurological function at 4 h and 3 d post-stroke without significantly increasing infarct volume.
MLN-4760 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-19414 | MLN-4760 | 305335-31-3 | 1mg | 1550 |
| 2025-12-22 | HY-19414 | MLN-4760 | 305335-31-3 | 10 mM * 1 mLin DMSO | 2968 |
