N6-Methyladenosine 5'-monophosphate sodium salt

N⁶-Methyladenosine 5''-monophosphate is an activator of glycogen phosphorylase b (K_a = 22 μM). It is also a non-competitive inhibitor of rat adenylate kinase II (K_i = 4.2 mM). N⁶-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N⁶-methyladenosine.

White to off-white free flowing powder

N⁶-Methyladenosine 5′-monophosphate sodium salt can be used in N⁶-methyladenosine (m⁶A) ribonucleoprotein immunoprecipitation reactions. m6A has gained a lot of attention in the recent years because the mRNA modification with m6A has been shown to play a role in stability and translational efficiency of mRNA.

N6-Methyladenosine-5''-monophosphate Sodium Salt is used in method for improving the yield of m6A antibody enriched methylated mRNA.

A glycogen phosphorylase b activator.

[1] MICHEL MORANGF. AMP Analogs: Their Function in the Activation of Glycogen Phosphorylase b[J]. The FEBS journal, 1976, 65 2: 553-563. DOI: 10.1111/j.1432-1033.1976.tb10373.x
[2] TON T. HAI. Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5’-phosphate derivatives[J]. Journal of Medicinal Chemistry, 1982, 25 7: 806-812. DOI: 10.1021/jm00349a008
[3] NATE J FRY. N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.[J]. RNA, 2017, 23 9: 1444-1455. DOI: 10.1261/rna.061044.117