Hexahydro-1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6-trione

1,3,5-Tris(2,3-dibromopropyl) Isocyanurate is a flame retardant that has applications in assessing potential bioaccumulation and impact on endocrine activity. It has been employed in flow-cytometric proliferation assay to determine potential estrogen-disruptive effects of flame retardants in MCF-7 cells.

tris(2,3-dibromopropyl) isocyanurate,TBC, is a new, efficient, and additive brominated flame retardants, flame retardant effect, low volatility, good compatibility, durable, light, water and non-toxic properties.

Tris(2,3-dibromopropyl) isocyanurate is a non degradable heterocyclic hexabrominated flame retardant. It inhibited the expression of psaA and psbC that led to the decrease of Nannochloropsis sp.′s growth biomass.

Tris(2,3-dibromopropyl) isocyanurate (TBC) is widely used in polymer products. It is ubiquitously found in environmental matrices. TBC inhibited basal and forskolin-induced sex hormone production but did not exhibit cytotoxicity. 

The properties of TBC, e.g., the high octanol–air partition coefficient (Koa), high octanol–water partition coefficient (Kow), and high bioconcentration factor (BCF), indicate a possibility of its spread in aquatic and terrestrial ecosystems and bioaccumulation in living organisms. The presence of TBC has been confirmed in soil, sediments, river water, and such materials as microplastic, curtains, and e-waste devices. The compound has potential to bioaccumulate in the food chain of living organisms. TBC has been demonstrated to exert a harmful effect mainly on the nervous and endocrine systems, lungs, and liver.