Neohesperidin

Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.

White powder, easily soluble in methanol and almost insoluble in ether, derived from trifoliate orange peel, sour orange immature fruit, and various citrus fruits.

Neohesperidin can be used in cosmetic products and as a sweetening agent in food & beverages, an antioxidant flavanone glycoside

Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity.

ChEBI: Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a neohesperidoside, a disaccharide derivative, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a monomethoxyflavanone, a flavanone glycoside and a member of 4'-methoxyflavanones. It is functionally related to a hesperetin.

[1] ZHEN TAN . Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice[J]. Molecular and Cellular Endocrinology, 2017, 439: Pages 369-378. DOI: 10.1016/j.mce.2016.09.026
[2] HAOSHU WU. Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis.[J]. Pharmacology, 2017, 100 3-4: 115-126. DOI: 10.1159/000452492
[3] JIA S, HU Y, ZHANG W, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice[J]. Food & Function, 2015, 3: 878-886. DOI: 10.1039/c4fo00993b