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5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2H-吲哚-2-酮

基本属性 生物活性体外研究体内研究 用途与合成方法 供应商 供应信息 相关产品
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2H-吲哚-2-酮
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2H-吲哚-2-酮 用途与合成方法
  • 生物活性Ziprasidone HCl 是一类有效的dopamine 和 serotonin (5-HT) receptor的拮抗剂,用于精神分裂症以及双向性障碍的治疗。
  • 体外研究Ziprasidone has high affinity for human 5-HT receptors and for human dopamine D(2) receptors. Ziprasidone is a 5-HT(1A) receptor agonist and an antagonist at 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptors. Ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. Ziprasidone blocks wild-type hERG current in a voltage- and concentration-dependent manner with IC(50) of 120nM in stably transfected HEK-293 cells. Ziprasidone shows minimal tonic block of hERG current estimated during a depolarizing voltage (-20 or +30mV) or evaluated by the envelope of tails test (+30mV). Ziprasidone significantly increases the time constant of the slow component of hERG current deactivation (at -50mV).
  • 体内研究Ziprasidone exhibits less potent block of wild-type hERG current with IC(50) of 2.8 mM in Xenopus oocytes. Ziprasidone suppresses the significant increases in food intake produced by olanzapine, indicating that it has an intrinsic protective mechanism against drug-induced increases in food intake in rats. Ziprasidone results in a notable increase in NGF and ChAT immunoreactivity in the dentate gyrus (DG), CA1, and CA3 areas of the hippocampus of rats. Ziprasidone dose-dependently slows raphe unit activity (ED50 = 300 mg/kg i.v.) as does the atypical antipsychotics clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats.
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2H-吲哚-2-酮供应商更多
  • 公司名称:上海书亚医药科技有限公司
  • 联系电话:4001-647-117; 021-61629020
  • 产品介绍: 中文名称:盐酸齐拉西酮
    英文名称:5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride
    CAS:122883-93-6
    纯度:98% 包装信息:1085RMB/10g 备注:试剂级
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  • 公司名称:上海瀚鸿科技股份有限公司
  • 联系电话:021-54306202,021-54308259
  • 产品介绍: 中文名称:盐酸齐拉西酮
    英文名称:Ziprasidone
    CAS:122883-93-6
    纯度:95% 备注:AB05560
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  • 公司名称:BOC Sciences
  • 联系电话:
  • 产品介绍: 英文名称:Ziprasidone Hydrochloride
    CAS:122883-93-6
    纯度:95%
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  • 公司名称:深圳菲斯生物科技有限公司
  • 联系电话:18165736994,4000505016
  • 产品介绍: CAS:122883-93-6
    纯度:95%+ HPLC 包装信息:10mg,25mg,50mg 备注:品牌:sinco,适用于药品研发生产和申报
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  • 公司名称:MedChemexpress LLC
  • 联系电话:609-228-6898
  • 产品介绍: 英文名称:Ziprasidone (hydrochloride)
    CAS:122883-93-6
    纯度:>98% 包装信息:515RMB/10mg 备注:试剂级
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"5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2H-吲哚-2-酮"相关产品信息