6-aminotetralin-2,3-diol

6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2 Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce excitatory synaptic transmission in the nucleus accumbens by activating presynaptic dopamine receptors.4

(+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide is a dopamine receptor agonist in Tribolium castaneum.

[1] S. LIST P S K Wreggett. Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4- tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics[J]. Journal of Neuroscience, 1982, 8 1: 895-906. DOI:10.1523/jneurosci.02-07-00895.1982
[2] WILMA W. TEMPLETON  Geoffrey N W. Binding of [3H]ADTN to rat striatal membranes[J]. Biochemical pharmacology, 1982, 31 8: Pages 1629-1632. DOI:10.1016/0006-2952(82)90391-4
[3] S B FREEDMAN. Expression and pharmacological characterization of the human D3 dopamine receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 268 1: 417-426.
[4] SM NICOLA R M SB Kombian. Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors[J]. Journal of Neuroscience, 1996, 112 1: 1591-1604. DOI:10.1523/jneurosci.16-05-01591.1996