阿比特龙代谢物
阿比特龙代谢物 性质
| 沸点 | 504.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.14±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：10mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 5.32±0.12(Predicted) |
| 颜色 | 白色至米色 |
| InChIKey | GYJZZAJJENTSTP-NHFPKVKZSA-N |
| SMILES | n1cc(ccc1)C2=CC[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5CC4)C)CC[C@@]32C |
阿比特龙代谢物 用途与合成方法
CYP17A1, 3βHSD, SRD5A, androgen receptor
D4-abiraterone (D4A ) (10 mM) nearly completely blocks conversion from D4-androstenedione (AD) to 5α-androstanedione and other 5α-reduced androgens. The affinity of D4-abiraterone for mutant (expressed in LNCaP, half-maximum inhibitory concentration (IC 50 =5.3 nM)) and wild type (expressed in LAPC4, IC 50 =7.9 nM) androgen receptor (AR) is greater than that of abiraterone (Abi) (IC 50 =418 and >500 nM, respectively). Compare with Abi, D4-abiraterone clearly better suppresses PSA, TMPRSS2 and FKBP5 expression in LNCAP, LAPC4 and C4-2 cell lines. D4-abiraterone also inhibits AR target gene expression in a dose-dependent manner.
D4-abiraterone (D4A) is tenfold more potent than abiraterone (Abi) in blocking conversion from dehydroepiandrosterone (DHEA) by 3β-hydroxysteroid dehydrogenase (3βHSD) to D4-androstenedione (AD) in LNCaP and VCaP xenografts. 0.1 μM D4-abiraterone is equivalent to 1 μM Abi for blocking AD accumulation at 48 h in both LNCaP and VCaP xenografts. Progression is significantly delayed in the D4-abiraterone group compare with the Abi acetate group (P=0.011). D4-abiraterone treatment increases progression-free survival compare with Abi acetate.
阿比特龙代谢物 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-109619 | 阿比特龙代谢物 | 154229-21-7 | 5mg | 1390 |
| 2026-06-05 | HY-109619 | 阿比特龙代谢物 | 154229-21-7 | 10mM * 1mLin DMSO | 1529 |
