Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml). It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 μg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively. In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia. Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%. Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
A broad spectrum antibiotic commonly used to target Pseudomonas and Staphylococci species
Fluorinated quinolone antibacterial
ChEBI: A fluoroquinolone antibiotic that is 7-oxo-2,3-dihydro-7H-[1,3,4]oxadiazino[6,5,4-ij]quinoline substituted at positions 6, 9 and 10 by carboxy, fluoro and 4-methylpiperazin-1-yl groups, respectively. A synthetic, broad spect
um bactericidal agent, it is used in veterinary medicine, although its mechanism of action is not thoroughly understood.
Marbofloxacin is an FDA-approved broad-spectrum bactericidal fluoroquinolone available in oral tablet and injectable forms. It has been shown to have varying therapeutic effects in a wide range of animal diseases in dogs, cats, horses, cattle and pigs. It can be used to treat skin and soft tissue infections in dogs and cats, urinary tract infections in dogs, some blood borne pathogens (e.g. Mycoplasma haematobium) in cats, equine infections caused by susceptible bacteria, bovine respiratory disease, and porcine respiratory disease pathogens.
The most common side effects of Marbofloxacin are vomiting, diarrhoea and loss of appetite. More serious side effects include cartilage abnormalities (which may cause difficulty walking), prolonged loss of appetite, incoordination, convulsions, depression, fever, rash, or difficulty breathing. Blindness and eye damage in cats has been a concern at high doses.
Veterinary Drugs and Treatments
Marbofloxacin is labeled for the treatment of susceptible bacterial
infections in dogs and cats.
