waltonitone

Product Namewaltonitone
CAS1252676-55-3
MFC30H48O2
MW440.7
EINECS
MOL File1252676-55-3.mol

Chemical Properties

Boiling point	521.6±50.0 °C(Predicted)
Density	1.05±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 15 mg/mL (34.04 mM);;
pka	15.09±0.10(Predicted)

Usage And Synthesis

Uses

Waltonitone is a pentacyclic triterpenoid compound isolated from waltonione. Some studies shown that Waltonitone is a potential anti-tumor drug which can inhibit the proliferation of lung cancer A549 cells and promote their apoptosis.

Biological Activity

Waltonitone is a kind of ursane-type pentacyclic triterpenes that can be extracted from the long-stemmed chinensis, which has antitumor activity.

in vitro

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells.
Waltonitone (25 μM; for 48 hours) induces BEL-7402 apoptosis cells.
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells.

in vivo

Waltonitone (iv; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo. < br/>