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Carmofur

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Carmofur Basic information
Carmofur Chemical Properties
  • Melting point:110-111
  • Density 1.2287 (estimate)
  • storage temp. 2-8°C
  • solubility DMSO: >15mg/mL
  • form powder
  • pka6.94±0.10(Predicted)
  • color white to off-white
  • Merck 14,1844
  • CAS DataBase Reference61422-45-5(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi,T
  • Risk Statements 60-61-25
  • Safety Statements 45
  • RIDADR UN 2811 6.1 / PGII
  • WGK Germany 3
  • RTECS UV7714000
  • Hazard Note Irritant
  • HazardClass 6.1
  • PackingGroup III
  • HS Code 29335990
MSDS
Carmofur Usage And Synthesis
  • OriginatorMifurol,Mitsui,Japan,1981
  • Usesantineoplastic
  • Manufacturing Process13.0 g (0.10 mol) of 5-fluorouracil was suspended in 60 ml of dimethyl acetamide, then 14.0 g (0.11 mol) of n-hexyl isocyanate was added thereto at room temperature and stirred at 50°C for 8 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into 400 ml of water and resultant precipitate was filtered off. The precipitate was washed and dried and 19.3 g (75.0% yield) of 5-fluoro-1-(n-hexylcarbamoyl)uracil was obtained.
    The product was recrystallized from ether and there were obtained white crystals melting at 283°C (decomposition).
  • Therapeutic FunctionAntineoplastic
Carmofur(61422-45-5)Related Product Information
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