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2-Methylpropanedioic acid

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2-Methylpropanedioic acid Basic information
2-Methylpropanedioic acid Chemical Properties
  • Melting point:128-130 °C (lit.)
  • Boiling point:272.71°C (rough estimate)
  • Density 1.45
  • refractive index 1.4304 (estimate)
  • Flash point:2℃
  • storage temp. Sealed in dry,Room Temperature
  • form Crystalline Powder
  • pka3.07, 5.76(at 25℃)
  • color White
  • Specific Gravity1.455
  • Water Solubility soluble
  • BRN 1756084
  • CAS DataBase Reference516-05-2(CAS DataBase Reference)
  • NIST Chemistry ReferenceMethylmalonic acid(516-05-2)
Safety Information
MSDS
2-Methylpropanedioic acid Usage And Synthesis
  • Chemical Propertieswhite crystalline powder
  • Uses2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
  • DefinitionChEBI: A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
  • Biological FunctionsMethylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
  • General Description
    Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
  • Purification MethodsThe acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
2-Methylpropanedioic acid Preparation Products And Raw materials
2-Methylpropanedioic acid(516-05-2)Related Product Information
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