N-(4-Ethynylphenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide is derived from 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic Acid (D478938), which is used as a reactant in the synthetic preparation of noninhibitory small molecule chaperones of glucocerebrosidase.