ChemicalBook > Product Catalog > API > Other Chemical drugs > Infection Prevention and Control of Epidemic > 1-(1-NAPHTHYL)-2-THIOUREA
1-(1-NAPHTHYL)-2-THIOUREA Chemical Properties
- Melting point:193 °C
- Boiling point:377.6±25.0 °C(Predicted)
- Density 1.333
- refractive index 1.5500 (estimate)
- storage temp. Poison room
- solubility 4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983)
- form Crystals or Crystalline Powder
- color Grayish to beige-brown
- Odorbitter taste
- Water Solubility 600 mg/L at 20 °C (quoted, Windholz et al., 1983)
- Merck 14,722
- BRN 778118
- Exposure limitsNIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3
- CAS DataBase Reference86-88-4(CAS DataBase Reference)
- EPA Substance Registry System.alpha.-Naphthylthiourea (86-88-4)
1-(1-NAPHTHYL)-2-THIOUREA Usage And Synthesis
- Chemical Propertiesgreyish to beige-brown crystals or cryst. powder
- Chemical PropertiesAlpha-naphthylthiourea (α-naphthalene thiourea) is a pure white or beige-brown solid/ blue-gray powder. It is hard to dissolve in water, acid, and general organic solvents, but dissolves in boiling ethanol and alkaline solution. On decomposition, ANTU releases carbon monoxide, toxic and irritating fumes and gases, and carbon dioxide. It is a rodenticide and a poison bait to lure rodents.
- Chemical PropertiesANTU is a noncombustible, white crystalline solid or gray powder. Odorless.
- Physical propertiesColorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
- UsesRodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
- General DescriptionWhite crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
- Air & Water ReactionsSlightly soluble in water.
- Reactivity Profile1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
- HazardToxic by ingestion
- Health HazardModerately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
- Health Hazardα-Naphthalene thiourea, a rodenticide, is very toxic and is fatal if swallowed. Exposures to ANTU cause poisoning with symptoms that include, but are not limited to, headache, weakness, dizziness, shortness of breath, cyanosis, blood abnormalities, methemoglobinemia, irritation of the digestive tract, liver and kidney damage, cardiac and CNS disturbances, convulsions, tachycardia, dyspnea, vertigo, tinnitus, weakness, disorientation, lethargy, drowsiness, and fi nally coma and death. The target organs include the blood, kidneys, CNS, liver, lungs, cardiovascular system, and blood-forming organs.
- Fire HazardEmits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
- Safety ProfilePoison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.
- Potential ExposureANTU or its formulations are used as a rodenticide.
- Environmental FateChemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was
determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Lewis, 1990)
- storageα-Naphthalene thiourea should be kept stored in a tightly closed container in a locked poison room, in a cool, dry, well-ventilated area away from incompatible substances.
- ShippingUN1651 Naphthylthiourea, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
- Purification MethodsCrystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
- IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, silver nitrate.
- Waste DisposalIncinerate in a furnace equipped with an alkaline scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
- PrecautionsWorkers should use/handle α-naphthalene thiourea with adequate ventilation. During use, dust generation and accumulation should be minimum, and avoid contact with the eyes, skin, and clothing.
1-(1-NAPHTHYL)-2-THIOUREA Preparation Products And Raw materials
- 1-(1-NAPHTHYL)-2-THIOUREA N-(9-PHENANTHRYL)THIOUREA 2H-NAPHTH[1,2-D]IMIDAZOLE-2-THIONE, 1,3-DIHYDRO- VITAS-BB TBB000589 N-METHYL-N'-1-NAPHTHYLTHIOUREA N-BENZOYL-N'-(9-PHENANTHRYL)THIOUREA 1H,3H-PERIMIDINE-2-THIONE N-ALLYL-N'-1-NAPHTHYLTHIOUREA 4-(1-NAPHTHYL)-3-THIOSEMICARBAZIDE N-(1-ANTHRYL)-N'-BENZOYLTHIOUREA N-(9-ANTHRYLMETHYL)-N-BENZOYL-N-METHYL-T TIMTEC-BB SBB006439 SALOR-INT L472417-1EA Piperidine, 1-(4-(((1-naphthalenylamino)thioxomethyl)amino)benzoyl)- N-METHYL-N'-(2-METHYL-1-NAPHTHYL)THIOUREA N-ETHYL-N'-1-NAPHTHYLTHIOUREA N-CYCLOHEXYL-N'-1-NAPHTHYLTHIOUREA N-(1-ANTHRYL)THIOUREA
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