THIQ
THIQ 性质
| 密度 | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：250 mg/mL（424.33 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.82±0.20(Predicted) |
| 颜色 | 白色至米白色 |
THIQ 用途与合成方法
THIQ maintains low potency at
human
MC1R, MC3R and MC5R with IC
50
s of 2067, 761, 326 nM and EC
50
s of 2850, 2487, 737 nM, resepectively. THIQ maintains low potency at
rat
MC3R and MC5R with IC
50
s 1883 and 1575 nM, and EC
50
s of 1325 and >3000 nM, respectively.
THIQ (10 μM; 24 hours) decreases the signal intensity of WT MC4R by approximately 50% whereas increases that of three mutants (N62S, C84R, and C271Y) in HEK293 cells.
THIQ (0.3-10 mg/kg; i.v.) dose-dependently increases erections (ED
50
=0.87 mg/kg) in sexually mature male Sprague Dawley rats. The maximal increase in the number of erections (60%) is detected at 5 mg/kg but was not significantly different from that produced by 1 mg/kg. THIQ (20 mg/kg; p.o.) also produces statistically significant increases in erectile responses with a mean increase of 31±4%.
THIQ treatment shows the t
1/2
is 0.6 hours in Sprague-Dawley rats (1 mg/kg, i.v. and 10 mg/kg, p.o.).
THIQ 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-10624 | 1 mg | 491 | ||
| 2024-04-30 | HY-10624 | THIQ | 312637-48-2 | 5mg | 1000 |
