Thioperamide is a highly potent and selective ligand for histamine H3-receptors.
ChEBI: Thioperamide is a primary aliphatic amine.
Potent histamine H 3 and H 4 antagonist/inverse agonist. K i values are 25 and 27 nM for human recombinant H 3 and H 4 receptors respectively. Blocks eosinophil shape change (IC 50 = 1.4 μ M) and chemotaxis (IC 50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H 3 Receptor Tocriset™ .
Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[3].
| Animal Model: | Naive female C57BL/6J mice[3] |
| Dosage: | 5, 10 or 20 mg/kg |
| Administration: | Injections (i.p.) |
| Result: | Facilitated reconsolidation of a contextually-conditioned fear memory. |
